MAP2K4

mitogen-activated protein kinase kinase 4
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Known Variants (dbSNP)
Harmful Beneficial Normal
- - 25
Novel Variants
Harmful Beneficial Normal
- - 2
Variants by Type Count
Insertions & Deletions 3
Known Variants (dbSNP) 25
With Severity Score 4
Total 27

Known vs. Novel Variants
Known Variants
25
Novel
2

Functional Consequence of Variants
Known Variants
Novel Variants
Known Variants Novel Variants
Harmful, Score > 3
0
0
Beneficial
0
0
Normal, Score 0-2
25
2

Gene Details  

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq]

research MAP2K4 on OMIM...
Pharmaceuticals  
FDA approved drugs to treat condition Click on drug names to see more info
None
Drugs in clinical trials
Some MAPK inhibitors in clinical trials

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