JAK2

Janus kinase 2
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Known Variants (dbSNP)
Harmful Beneficial Normal
- - 48
Novel Variants
Harmful Beneficial Normal
- - 7
Variants by Type Count
Insertions & Deletions 1
Known Variants (dbSNP) 48
With Severity Score 2
Total 55

Known vs. Novel Variants
Known Variants
48
Novel
7

Functional Consequence of Variants
Known Variants
Novel Variants
Known Variants Novel Variants
Harmful, Score > 3
0
0
Beneficial
0
0
Normal, Score 0-2
48
7

Gene Details  

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq]

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Pharmaceuticals  
FDA approved drugs to treat condition Click on drug names to see more info
None
Drugs in clinical trials
INCB18424

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